Pyometra is a serious infection of the uterus. Intact female dogs and unneutered cats are at higher risk of getting the infection. Symptoms of pyometra appear after few weeks of heat cycle that did not result in pregnancy because it is when the uterus will undergo changes. Symptoms of pyometra include vomiting, loss of appetite, frequent urination, lethargy, and foul-smelling vaginal discharge. Pus discharge from the uterus is a major clinical sign. Diagnosis is based on physical examination and x-rays of the abdomen to identify the enlarged uterus, the thickness of uterine walls, and the accumulation of fluid within the uterus. The preferred treatment is to surgically remove the uterus and ovaries. There is medical treatment too which involves prostaglandin therapy. It includes hormones that cause the uterus to contract to expel the bacterial and pus from it. However, it not always a successful treatment.